2013;98(8):E1283-E1304. My vitamin b12 Level is too high. Thank you. Rarely, a high level of vitamin B12 may be caused by diabetes or obesity, according to WebMD. This includes swelling of the face, tongue, and throat, and difficulty swallowing and breathing. No research has yet found any side effects from taking too much vitamin B-12. Clinically, it can be paradoxically accompanied by signs of deficiency, reflecting a functional deficiency linked to qualitative abnormalities, which are related to defects in tissue uptake and action of vitamin B12. With cancers involving the liver, there can also be a buildup of vitamin B12 in the blood due to decreased clearance by the diseased liver. Older adults with a vitamin B12 level less than 100 pg/mL (74 pmol/L) may also have symptoms. Vitamin B12 lowers the level of homocysteine. Moreover, preliminary evidence suggests that high serum folate levels might not only mask vitamin B12 deficiency, but could also exacerbate the anemia and worsen the cognitive symptoms associated with vitamin B12 deficiency [6,11]. High vitamin B12 levels are not associated with any particular symptoms. So clearly if you have high B12, you need to get to the bottom of why this is. Folate (>3.0 ng/mL) 14.3. 2013;32(3):375-381. doi:10.1016/j.clnu.2012.08.014, Marcinowska-Suchowierska E, Kupisz-Urbańska M, Łukaszkiewicz J, Płudowski P, Jones G. Vitamin D Toxicity-A Clinical Perspective. You can’t overdose on B12, and the risk is just too high. Health Effects of High Levels. A 12-week double-blind randomized clinical trial of vitamin D₃ supplementation on body fat mass in healthy overweight and obese women. No Tolerable Upper Intake Level (UL) has been established for B12, due to its low level of toxicity. A person with vitamin B12 deficiency may feel weak and fatigued. Increased vitamin B12 levels are uncommon, because excess vitamin B12 is usually eliminated with urine. Arch Intern Med. High vitamin B12 means levels are higher than 1,500 picograms per milliliter. Vitamin B12 is an essential nutrient, useful for maintaining blood and nerve health, and can be found in foods like sardines and eggs.. On top of that, we know that only a small percentage of vitamin B12 taken orally is actually absorbed. It appears that the more important question to be answered when you have high vitamin B12 levels is WHY you have high B12 as opposed to whether having too much of this vitamin can be toxic. High blood B12 levels can occur in liver conditions such as cirrhosis and hepatitis. Vitamin B12 Test and Extremely High Blood Levels Whilst low blood levels of vitamin B12 indicate deficiency in a test ; elevated blood levels are also often discovered. Holick MF. High levels of Vitamin B12 may be too much of a good thing. High levels of Vitamin B12 may be too much of a good thing. High B12 levels in the blood can be the result of liver disease, kidney failure and blood cancers. An increased blood level of vitamin B12 is sometimes caused by kidney disease, including diabetic kidney disease. Copyright © 2021 Leaf Group Ltd., all rights reserved. When taken at appropriate doses, vitamin B-12 supplements are generally considered safe. Nutr J. Both sets revealed high Hematocrit and Hemaglobin counts and the second set also had a test for B12. High Cbl levels result from unknown causes, possibly some kind of malignant process. Take all high-dose B12 supplements, B12 injections, and B12 nasal gel under direct supervision of a health care provider (especially if you're taking medications) and report any side effects to your doctor immediately. Vitamin D deficiency in minority populations. If you have high blood levels of B12 there are two possible causes, with different solutions… 1. if you consume a lot of B12 supplements then stop taking those supplements. One of the main causes of increased vitamin B12 with liver disease is release of stored vitamin by liver cells that have died due to the disorder. If that is the case, then stop taking them and/or reduce the doses. Am J Clin Nutr. High levels of Vitamin B12 may be too much of a good thing. Anxiety 4. High vitamin B12 levels are associated with many blood diseases, including various types of leukemia and related blood disorders. University of Ottawa Evidence-based Practice Center. Excessive levels of B12, he said, “might change the gut microbiota in ways that could be harmful — no one really knows.”, Still, Dr. Bakker said, “Our finding was only an association” and could not prove “a cause-and-effect relationship.”. 2011;96(7):1-2. doi:10.1210/jcem.96.7.zeg33a, Sunyecz JA. what causes extremely high serum vit b12 levels? 2010 91:1255-60. 25-hydroxyvitamin D and Risk of Myocardial Infarction in Men: a Prospective Study. Heaney, Robert P. “The Vitamin D Requirement in Health and Disease.” The Journal of Steroid Biochemistry & Molecular Biology 97 (2005):13-9. :1-2. doi:10.1210/jcem.96.7.zeg33a, Sunyecz JA Flynn MG, Pinkston C, et al cardiovascular disease ) in overweight... Tox... Read more had some blood work repeated from when he was healthy! Unknown causes, possibly some kind of malignant process, Manson JE, Abrams SA, al. Top of that, we vitamin b12 levels too high that only a small percentage of vitamin B12 deficiency:... 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